Endocrine Abstracts

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It results from various factors including erythropoietin (EPO) deficiency and inflammation. The aim of this study was to evaluate clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy. We investigated 95 anemic patients with type 2 diabetes mellitus and chronic kidney disease (stages 1–3). Glomerular filtration rate...

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It results from various factors including erythropoietin (EPO) deficiency and inflammation. The aim of this study was to evaluate clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy. We investigated 95 anemic patients with type 2 diabetes mellitus and chronic kidney disease (stages 1–3). Glomerular filtration rate...

Introduction and aims: Numerous studies in recent years have confirmed the existence of a link between endothelial dysfunction and vascular diseases, and lifestyle factors such as obesity, sedentary lifestyle and smoking.Methods: We examined 108 patients with obesity (90 women and 18 men, mean age 54.62±0.4 years). All patients underwent clinical and laboratory examination. Vasomotor endothelial function was evaluated by reactive hyperemia using ult...

Materials and methods: A survey was 95 people (45 people with diabetes mellitus type 1, 50 people with diabetes mellitus type 2). The age of examined patients 39.12±3.8. The disease duration ranged from 6 to 20 years. Level of biochemical indicators – normal limits. Condition of mineral density of a bone tissue it was estimated by method of a dual-energy X-ray absorptiometry (DEXA). The analysis of DEXA researches showed that change of mineral density of a bone tissu...

Aims: Anaemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy. In our previous studies we have shown that haemoglobin level has a negative correlation with serum levels of proinflammatory cytokines in this clinical group. It could be hypothesised that treatment of anaemia has anti-inflammatory effects. The aim of this study was to assess the influence of treatment with erythropoietin alpha on serum level of tumour ne...

Introduction and aims: Obesity is associated with increased single-nephron glomerular filtration rate, which may increase the risk of chronic kidney disease (CKD). Several biopsy studies showed the association between obesity and higher prevalence of CKD features, including segmental glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arterial sclerosis. Another approach is to study intra-renal hemodynamics by ultrasound, where renal parenchymal damage in obesity m...

Introduction: Anemia is associated with an increased risk of cardiovascular events and death in patients with diabetic nephropathy (DN). However, there are still a lot of contradictions related to the benefits and risks of antianemic treatment in this group of patients due to variety of non-hematopoietic effects of erythropoietin. The aim of this study was to assess the influence of erythropoietin therapy on renal function and proteinuria in patients with early DN.<p class...

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It may result from various factors including erythropoietin (EPO) deficiency, iron and vitamin deficiencies, systemic inflammation, adverse effects of some drugs and others. However, the clinical significance of each factor is not fully known. The aim of this study was to assess the relative contribution of EPO deficiency, iron deficiency and systemic infla...

Introduction: Autoimmune thyrotoxicosis (AT) affects 2-5% of the Western population. Despite current NICE guidelines recommending radioiodine as first-line treatment for AT, practical considerations such as licensing often prevent this. Typically, anti-thyroid medication (carbimazole or propylthiouracil) is initially offered. Patients are usually counselled that the remission rate following a 12-18 month course of anti-thyroid medication is approximately 50%.<p class="abst...

There is growing evidence that platelet indices correlate with functional status of platelets and with the risk of cardiovascular events. In this study we aimed to assess clinical correlates of mean platelet volume (MPV) in patients with abdominal obesity from different age groups. We investigated 111 adults with abdominal obesity, not receiving antiplatelet therapy. Abdominal obesity was defined in accordance with IDF criteria (2006). Group 1 included 44 patients aged 26&#150...